And the glucagon part doesnt appear to push meaningful high blood sugar in people without diabetes, which was the obvious worry going in, so on the safety profile thats the genuinely reassuring bit
Extraction Unripe durian fruit pulps were freeze-dried and ground into a fine powder
Dosing: Weekly subcutaneous injection Maximum dose: 15 mg/week Average weight loss (SURMOUNT-1): 20% over 72 weeks at the highest dose List price: ~$1,086/mo Self-pay: From $399/mo via LillyDirect FDA-approved for: Adults with BMI 30 (or 27 with comorbidities) Side-by-Side Comparison Side Effects: Similar, but Worth Reading Both medications have GLP-1-class side effects: nausea, diarrhea, vomiting, constipation, abdominal pain
FDA's Latest GLP-1 Crackdown: What Compounders and Telehealth Platforms Need to Know
However, long-term exposures may be able to reduce gut microbiome diversity and promote mycosis